Blar i forfatter "Anderssen, Endre"

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    • Analysis of methylation data with imputation with blocks (MethylBlocks) 

      Meng, Wei; Ray, Mithlesh Kumar; Fenton, Christopher Graham; Anderssen, Endre; Paulssen, Ruth H (Conference object; Konferansebidrag, 2022)
      <p><i>Background -</i> Analysis of methylation data is dependent on two inputs. The total number of reads at any given cytosine site (coverage), and how many of those cytosines are methylated (methylation). Both the large number of sites and low coverage can cause problems in the analysis of methylation data. Likewise finding DMR is computationally and statistically challenging. Here we present a ...

    • Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study 

      Krum-Hansen, Sanda; Standahl-Olsen, Karina; Anderssen, Endre; Frantzen, Jan Ole; Lund, Eiliv; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-08)
      Background Normal breast tissue is utilized in tissue-based studies of breast carcinogenesis. While gene expression in breast tumor tissue is well explored, our knowledge of transcriptomic signatures in normal breast tissue is still incomplete. The aim of this study was to investigate variability of gene expression in a large sample of normal breast tissue biopsies, according to breast cancer related ...

    • DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis 

      Taman, Hagar; Fenton, Christopher Graham; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
      Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ...

    • Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation 

      Villatoro, Alicia; Cuminetti, Vincent; Bernal, Aurora; Torroja, Carlos; Cossío, Itziar; Benguría, Alberto; Ferré, Marc; Konieczny, Joanna; Vázquez, Enrique; Rubio, Andrea; Utnes, Peter Andree; You, Xiaona; Fenton, Christopher Graham; Paulssen, Ruth H; Zhang, Jing; Sánchez-Cabo, Fatima; Dopazo, Ana; Vik, Anders; Anderssen, Endre; Hidalgo, Andres; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
      Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and the IL-1β monoclonal antibody canakinumab reduce the expansion of leukemic cells, including CD34+ ...

    • Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Fenton, Christopher Graham; Anderssen, Endre; Sørbye, Sveinung Wergeland; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      <i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ...

    • Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-22)
      <p><i>Background and Aims</i>: The aim of this study was to investigate the genome-wide DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the relationship between DNA methylation patterns and gene expression levels in tissue biopsies from a well-stratified treatment-naïve UC patient group.</p> <p><i>Methods</i>; Mucosal biopsies from treatment-naïve patients [n = ...

    • Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura : The emerging Gene Portrait of the Mesothelioma Phenotype 

      Olsen, Karina Standahl; Røe, Oluf Dimitri; Anderssen, Endre; Helge, Eli; Pettersen, Caroline Hild; Sandeck, H; Haaverstad, Rune; Lundgren, Steinar; Larsson, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model 

      Singh, Amrinder; Anderssen, Endre; Fenton, Christopher Graham; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      <p><i>Motivation:</i> Resistance to anti-TNF therapy in subgroups of ulcerative colitis (UC) patients is a major challenge and incurs significant treatment costs. Identification of patients at risk of nonresponse to anti-TNF is of major clinical importance. To date, no quantitative computational framework exists to develop a complex biomarker for the prognosis of UC treatment. Modelling patient-wise ...

    • Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis. 

      Singh, A.; Fenton, Christopher Graham; Anderssen, Endre; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-11)
      Background - In ulcerative colitis (UC), the molecular mechanisms that drive disease development and patient response to therapy are not well understood. A significant proportion of patients with UC fail to respond adequately to biologic therapy. Therefore, there is an unmet need for biomarkers that can predict patients’ responsiveness to the available UC therapies as well as ascertain the most ...

    • Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma 

      Røe, Oluf Dimitri; Szulkin, Adam; Anderssen, Endre; Flatberg, Arnar; Sandeck, Helmut; Amundsen, Tore; Erlandsen, Sten Even; Dobra, Katalin; Sundstrøm, Stein Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Pemetrexed, a multi-folate inhibitor combined with a platinum compound is the first-line treatment of malignant mesothelioma, but median survival is still one year. Intrinsic and acquired resistance to pemetrexed is common, but its biological basis is obscure. Here we report for the first time a genome-wide profile of acquired resistance in the tumour from an exceptional case with advanced pleural ...

    • Mucosal gene transcription of ulcerative colitis in endoscopic remission 

      Arkteg, Christian Børde; Goll, Rasmus; Gundersen, Mona Dixon; Anderssen, Endre; Fenton, Christopher Graham; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
      <i>Aim/Objective</i>: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. In UC, a wide range of criteria are used for disease remission, with few studies investigating the differences between disease remission and normal control groups. This paper compares known inflammatory and healing mediators in the mucosa of UC in clinical remission and normal controls, in order to better describe ...

    • Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
      Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease [IBD]. This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared ...